治疗儿童腹的低度口服补水溶液:系统性审查和元分析
Mustafa Bin Ali Zubairi1, Syeda Kanza Naqvi1, Ayesha Arshad Ali1
1Institute for Global Health and Development, Aga Khan University, Karachi, Pakistan.
Journal of global health
|December 6, 2024
概括
低度口服补水溶液 (LORS) 显著减少了儿童的腹持续时间和便量. 这支持当前世界卫生组织 (WHO) 关于治疗急性和持续性腹的建议.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 标准口服补水溶液 (ORS) 配方 (311 mmol/L) 被广泛用于腹管理.
- 对高血的担忧导致了低透度ORS (LORS) 的发展,透度≤245 mmol/L.
- 本系统性审查评估了LORS与标准ORS对急性和持续性腹的疗效.
研究的目的:
- 评估低度ORS (LORS) 与标准ORS相比在治疗10岁以下儿童急性和持续性腹方面的有效性.
- 为世界卫生组织 (WHO) 关于儿童腹管理指南的修订提供信息.
主要方法:
- 对1990年以后发表的研究进行系统审查和元分析.
- 搜索了多个数据库,包括PubMed,Scopus和WHO ICTRP.
- 使用Cochrane偏差II风险评估偏差风险和使用GRADE的证据质量.
主要成果:
- 在急性腹中,LORS显著降低了腹持续时间,便量和ORS摄入量 (中度至非常低的确定性证据).
- 对于急性腹的治愈率和治疗失败 (低确定性证据) 观察到类似的效果.
- 在持续性腹中,LORS还显著减少了腹持续时间,便量和ORS摄入量.
结论:
- 低度ORS (LORS) 是有效的,应该推给10岁以下的儿童,急性水性或持续性腹.
- 这些发现支持并支持当前世界卫生组织 (WHO) 对LORS使用的建议.
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