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伊塔康酸寡合体用于静电螺旋可降解可植入的生物基聚氨

Mengqiu Quan¹, Minghui Cui¹, Genzheng Sha¹

¹Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province, Laboratory of Polymers and Composites, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, Zhejiang, P. R. China.

ACS applied bio materials

|December 6, 2024

概括

研究人员使用微波合成开发了一种新的可植入的医疗聚氨 (IBP-PU). 由于其强度,生物相容性和受控的降解,这种材料对管状器官移植有希望.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
医疗设备工程医疗设备工程

背景情况:

心血管和胆道疾病需要有效的替代性手术.
商业材料和天然移植的有限可用性突显出需要新的可植入解决方案.
开发管状植入材料对于治疗器官疾病至关重要.

研究的目的:

合成和表征一种具有二进制软段结构的新型可植入医疗聚氨 (IBP-PU).
评估合成IBP-PU的机械,热和生物相容性特性.
评估材料的降解概况和适用于管状移植的适用性.

主要方法:

使用微波合成来准备具有二进制软段结构的IBP-PU.
进行了机械测试 (强度,断裂时的应变) 和热力学分析 (T_d5%).
生物相容性通过血液溶解速率和细胞存活测试进行评估.
静电线被用来制造管状结构.

主要成果:

IBP-PU表现出优异的机械性能 (33.00 ± 4.02 MPa强度,519.93 ± 53.44%在断裂时的应变).
该材料表现出稳定的热力学性能 (T_d5%>>250°C) 和出色的生物相容性 (2.55%的血液溶解,>100%的细胞存活率).
一个5毫米口径的管状植入物成功地使用静电旋转制造出来,显示出适当的降解率.

结论:

合成的IBP-PU具有卓越的机械和热稳定性,以及出色的生物相容性.
该材料的受控降解和无毒副产品使其适合长期植入.
IBP-PU是小口径心血管,胆道和其他体内管状移植的有希望的候选人.

关键词:

基于生物的软细分市场.静电线电静电线可以植入的医疗材料.伊塔康酸是什么意思聚氨是一种聚氨.

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