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饮食炎症指数得分与发生痴呆症之间的关联
Debora Melo van Lent1,2,3, Hannah Gokingco Mesa1, Meghan I Short1,4
1Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas, USA.
通过更高的饮食炎症指数 (DII) 评分来表明的促炎症饮食与患痴呆症的风险增加有关,包括阿尔茨海默病 (AD). 相反,抗炎饮食可能有助于预防晚年认知能力下降.
科学领域:
- 营养流行病学 营养流行病学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 饮食炎症指数 (DII) 量化了饮食的炎症潜力.
- 了解饮食对认知健康的影响对于公共健康至关重要.
- 以前的研究表明,饮食和痴呆风险之间存在联系.
研究的目的:
- 调查较高的DII得分与所有原因痴呆和阿尔茨海默病 (AD) 痴呆的发病率之间的关联.
- 在长期跟踪期间,在社区基队列中检查这种关系.
主要方法:
- 利用了来自弗雷明汉心脏研究后代队列的1487名参与者的数据.
- 在最多三个时间点使用食物频率问卷 (FFQ) 评估饮食摄入量.
- 在13.1年的中位数随访期间,监测了所有原因的痴呆症和AD事件.
主要成果:
- 较高的DII得分与所有原因痴呆的发病率增加显著相关 (HR 1.21,P < 0.001).
- 更高的DII分数也与阿尔茨海默氏症痴呆症发病率的增加有关 (HR 1.20,P = 0.001).
- 在调整了人口统计,生活方式和临床因素后,这些关联仍然很重要.
结论:
- 较高的DII分数表明患痴呆症的风险更高,包括AD.
- 这些发现表明,以低DII分数为特征的饮食可能在预防晚年痴呆症方面发挥作用.
- 需要进一步的验证和复制研究来证实这些有希望的结果.
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