在中国西南地区建立PIVKA-II的性别特定参考间隔:现实世界数据分析
Bin Wei1, Yalin Zheng1, Lixin Li1
1Department of Laboratory Medicine/Clinical Research Center of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Annals of clinical biochemistry
|December 6, 2024
概括
这项研究使用现实世界的数据在中国西南地区为PIVKA-II建立了性别特定的参考间隔. 新的间隔,男性0-35mAU/mL,女性0-29mAU/mL,改善了本地PIVKA-II测试的解释.
科学领域:
- 临床化学 临床化学
- 生物标志物发现发现
- 参考区间的建立 参考区间的建立
背景情况:
- 准确地解释PIVKA-II水平对于临床决策至关重要.
- 现有的PIVKA-II参考间隔对于中国西南地区的人口可能不是最佳的.
- 针对性别的参考间隔对于精确的诊断评估至关重要.
研究的目的:
- 在中国西南部为PIVKA-II建立与性别相关的参考间隔 (RIs).
- 使用大量现实世界的数据集来进行可靠的RI确定.
- 为改善临床实用性提供特定人群的PIVKA-IIRI.
主要方法:
- 收集了来自中国西南部120780名健康成年人的PIVKA-II数据.
- 应用统计方法,包括Box-Cox转换和Tukey异常值识别.
- 使用标准正常偏差测试来按年龄和性别分层RI.
主要成果:
- 在中国西南部人口中确立了特定于性别的PIVKA-II RIs.
- 正常分布方式:0-35 mAU/mL (雄性),0-29 mAU/mL (雌性).
- 非参数方法:0-32 mAU/mL (雄性),0-28 mAU/mL (雌性) 的方法.
结论:
- 已建立的PIVKA-II RI是针对中国西南部人口的.
- 这些性别特定的RI为PIVKA-II级别的解释提供了更准确的指导.
- 这些发现支持在临床实践中使用局部化和性别分层的参考间隔.
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