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农田的接近与肌缩性侧面硬化症的发病率和发病时的年龄有关

Umberto Manera^1,2, Stefano Callegaro¹, Antonio Canosa^1,2,3

¹"Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.

European journal of neurology

|December 6, 2024

概括

靠近耕作作物生活与患有肌缩侧面硬化症 (ALS) 的风险更高有关. 靠近这些作物似乎也降低了ALS患者的发病年龄.

科学领域:

环境流行病学环境流行病学
神经退行性疾病研究
公共卫生公共卫生

背景情况:

肌缩侧面硬化症 (ALS) 是一种复杂的神经退行性疾病,受遗传和环境因素的影响.
以前的研究表明,农村生活可能是ALS的风险因素,但尚未全面研究发病率,发病年龄和表型.
这项研究调查了耕地邻近对ALS的特定影响.

研究的目的:

评估住宅靠近耕地与ALS发病率之间的关联.
评估耕地暴露对ALS表型的影响,特别是发病年龄,发病地点和进展率.

主要方法:

从皮埃蒙特和阿奥斯塔谷登记处 (PARALS) 诊断出在2007年至2014年期间的ALS患者的利用地址史.
与诊断前20年的市政作物覆盖率相比,每年的ALS发病率均化.
根据周围的居住区在可变的半径计算了农田近距离得分,以分析暴露和表型.

主要成果:

市区的耕作作物的比例较高与ALS发病率的增加相关 (R=0.191,p<0.001).
居住在耕作作物附近的患者经历了显著较早的发病年龄,预期的中位数为1.8至3.4年.
历史数据还表明,葡萄园附近居住的患者的发病年龄较早.

结论:

在耕作作物附近和增加ALS风险之间建立了直接联系.
发现耕作作物/葡萄园的邻近和ALS发病年龄之间存在反向联系.
表明与耕地相关的特定环境污染物可能在ALS中起因作用.

关键词:

骨髓缩侧面硬化症 (ALS) 是一种农作物耕地农作物耕地农作物耕地环境风险因素环境风险因素地理空间流行病学杀虫剂杀虫剂杀虫剂

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