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相关概念视频

Allergic Reactions02:06

Allergic Reactions

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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

748
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
748
Antibody Structure01:10

Antibody Structure

59.0K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Active versus Passive Immunity01:31

Active versus Passive Immunity

567
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
567
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

455
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Correspondence: The First Biosimilar for Biologics in Allergy: CT-P39 (Omlyclo-Omalizumab-Igec) Is Available for Asthma, Chronic Spontaneous Urticaria, and Chronic Rhinosinusitis With Nasal Polyps.

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Antigenic Liposomes for Generation of Disease-specific Antibodies
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过敏原特定免疫疗法和训练免疫力

Leticia Martín-Cruz1,2, Oscar Palomares1

  • 1School of Chemistry, Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.

Allergy
|December 6, 2024
PubMed
概括

训练免疫 (TRIM) 在过敏和过敏原特异性免疫疗法 (AIT) 中起着至关重要的作用. 天生的免疫细胞中的TRIM机制为开发有效的过敏疫苗和治疗提供了新的策略.

科学领域:

  • 免疫学 免疫学 免疫学
  • 过敏研究 研究过敏
  • 具有天生的免疫力.

背景情况:

  • 由于遗传,生活方式和环境因素,过敏性疾病很普遍.
  • 过敏原特异性免疫疗法 (AIT) 是一种可以改变疾病进程的关键治疗方法.
  • 最近的研究强调了适应性和先天性免疫反应在AIT耐受性中的作用.

研究的目的:

  • 探索训练免疫 (TRIM) 在过敏疾病和AIT中的作用.
  • 研究天生的免疫细胞中的TRIM机制如何促进过敏的发展和预防.
  • 根据TRIM识别基于新型过敏疫苗的潜在目标.

主要方法:

  • 对将TRIM与过敏和AIT联系起来的实验证据的审查.
  • 对TRIM在早期免疫反应和环境暴露中的作用的分析.
  • 基于TRIM的疫苗和下一代AIT战略的评估.

主要成果:

  • 早期不适应的TRIM反应可能会促进2型炎症和过敏.
  • 接触某些环境和微生物可以预防过敏,部分是通过TRIM.
  • 基于TRIM的疫苗已经证明具有保护性的抗过敏作用.
关键词:
过敏原特定免疫疗法喘 喘 是一种食物过敏 食物过敏代谢和表观遗传重新连接.训练有素的免疫力受过训练的基于免疫的过敏原疫苗.训练有素的基于免疫的疫苗 (TIbV)

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相关实验视频

Last Updated: Jun 5, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency

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结论:

  • 训练有素的免疫力是过敏病原和AIT的重要因素.
  • 了解TRIM机制可以为过敏性疾病带来新的治疗方法.
  • 开发基于TRIM的过敏原疫苗对未来的过敏治疗有希望.