以色列儿童生长激素治疗:一项大规模的回顾性数据库研究
Yael Reichenberg1, Rachel Bello2,3, Bernice Oberman1
1Dan-Petach Tikva District, Clalit Health Services, Tel Aviv, Israel.
Acta paediatrica (Oslo, Norway : 1992)
|December 6, 2024
概括
早期生长监测对于身高矮小的儿童,特别是女孩和少数群体至关重要,以确保及时进行复合生长激素 (GH) 治疗,并改善成人身高结果.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 增长激素治疗疗法 增长激素治疗
- 公共卫生 公共卫生
背景情况:
- 矮身影响着大量的儿科患者,需要对治疗途径进行评估.
- 重组生长激素 (GH) 治疗是各种矮身疾病的关键干预措施.
- 了解特定地区的治疗模式对于优化护理至关重要.
研究的目的:
- 分析以色列儿童复合GH疗法的指示,患者人口统计和治疗时间表.
- 为了确定影响启动GH治疗矮身的因素.
主要方法:
- 从2010年到2021年在以色列接受GH治疗的5148名儿童的医疗图表的回顾性审查.
- 数据收集包括人口统计,诊断,诊断时间和GH治疗持续时间.
- 分析人口特征,包括社会经济地位和种族.
主要成果:
- 异常性矮身 (ISS) 是最常见的征兆 (64.1%),其次是GH缺乏 (GHD) (31.1%).
- 增生激素治疗始于9.8岁的平均年龄,男性治疗的频率高于女性.
- 该队列代表了不同的社会经济和种族群体,包括高SES (51.2%),非极端正统犹太人 (78.2%),极端正统犹太人 (13%) 和阿拉伯人 (8.8%).
结论:
- 儿童早期及时进行成长评估对于所有儿童来说都是必不可少的.
- 应特别注意女性,低社会经济地位的个人和少数群体,以便适当的转诊和治疗.
- 优化GH治疗的启动可以改善最终成年人身高的结果.
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