与注册去中心化研究相关的因素
Adil E Bharucha1, Michelle L Bublitz2, Robert A Vierkant3
1Division of Gastroenterology and Hepatology, Rochester, MN, USA.
Mayo Clinic proceedings
|December 6, 2024
概括
与电子邮件相比,电子健康记录邀请显著提高了参加大型DNA测序研究的入学率. 改进的邀请函设计并没有提高报名率,突出了针对代表性不足的群体进行有针对性的宣传的需要.
科学领域:
- 基因组医学是基因组医学.
- 临床试验招聘 临床试验招聘
- 医疗信息学 医疗信息学
背景情况:
- 分散的研究研究需要有效的患者招募策略.
- 研究邀请的模式和格式可能会影响入学率.
- 优化招聘对于大规模遗传研究的成功至关重要.
研究的目的:
- 评估邀请发送方法 (电子健康记录与电子邮件) 对患者招生的影响.
- 为了确定增强的邀请格式是否会影响参与DNA测序研究.
- 确定与分散的研究环境中的入学率相关的人口和临床因素.
主要方法:
- 展望性对比的邀请策略的挂毯DNA测序研究研究.
- 第一个阶段:随机选择患者进入电子健康记录 (EHR) 门户或电子邮件邀请.
- 第二阶段:随机选择患者,通过电子健康记录或电子邮件发送标准或增强的邀请.
主要成果:
- 与第一阶段 (2.52%) 相比,第二阶段 (7.27%) 的入学率更高.
- 电子健康记录邀请结果显著高于电子邮件邀请的入学率 (OR,1.56).
- 改进的邀请函设计并没有显著影响入学率.
- 女性,老年人 (50-70岁),白人/非西班牙裔个人,城市居民和最近接受过医疗保健的人群的入学率更高.
结论:
- 电子健康记录邀请比电子邮件更有效,用于招募大型分散研究的参与者.
- 邀请函设计的改进并没有提高招生率,这表明应该把重点放在发送道上.
- 男性,年轻人,非白人/西班牙裔个人和农村居民的入学率较低,需要有针对性的招聘策略.
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