基于氧化物的自我供应纳米平台,通过光热增强化学动力疗法有效地消灭细菌

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Fuqiang Shi¹, Jie Chen¹, Lesan Yan^1,2

¹State Key Laboratory of Advanced Materials Synthesis and Processing Technology, Wuhan University of Technology, Hubei Provincial Biomedical Materials and Engineering Research Center, Wuhan 430070, China.

ACS applied materials & interfaces

|December 6, 2024

概括

这项研究介绍了一种新的纳米平台 (CSPC),可以增强细菌感染的化学动力学疗法 (CDT) 和光热疗法 (PTT). CSPC自供应过氧化,并消耗谷,促进基生成,以有效地消灭细菌和治愈伤口.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
抗菌疗法是一种抗菌疗法.

背景情况:

化学动力学疗法 (CDT) 通过通过芬顿反应产生基基 (•OH) 来治疗细菌感染.
感染部位的低内源性过氧化 (H2O2) 和高谷氨 (GSH) 水平限制了CDT的疗效.
现有的治疗方法与细菌耐药性和生物膜形成作斗争.

研究的目的:

为增强协同光热疗法 (PTT) 和化学动力疗法 (CDT) 开发一个多功能纳米平台.
在感染微环境中克服H2O2可用性和GSH过度表达的局限性.
创建一个核心纳米结构,以有效地消除细菌和破坏生物膜.

主要方法:

使用过氧化 (CaO2), (SiO2) 和 (II) 合的多多巴胺 (PDA) 制造一个核心外纳米结构 (CaO2@SiO2@PDA-Cu,CSPC).
评估CSPC的H2O2自我供应,GSH耗尽和增强的光热特性.
评估协同PTT/CDT抗菌活性对抗大肠杆菌和黄金菌菌,包括生物膜抑制.
在体内测试细菌根除和伤口愈合的有效性.

主要成果:

通过芬顿式反应,CSPC证明了通过释放的Cu (II) 和H2O2.2,增强的OH基的高效生成.
该纳米平台有效地耗尽了GSH,并在近红外 (NIR) 照射时表现出高光热转换效率 (43%).
在60μg/mL时,完全消除了大肠杆菌和金黄色杆菌,并显著消除了金黄色杆菌生物膜 (65.90±3.46%).
在体内研究表明有效的细菌根除 (6.56 ± 3.28%的存活率) 和加速伤口愈合.

结论:

开发的CSPC纳米平台为抗击细菌感染提供了一个有前途的双模式PTT/CDT战略.
CSPC有效地解决了H2O2缺乏和GSH过度表达,从而提高了抗菌功效.
这种多功能纳米材料显示出治疗细菌感染和促进伤口愈合的巨大潜力.

关键词:

芬顿式反应是一种类似芬顿反应的反应.自给自足的H2O2可以自给自足谷氨缺乏症谷氨缺乏症协同疗法是一种协同疗法.伤口愈合伤口愈合

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