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在多发性硬化症患者中,TWEAK 和 TNFɑ 支持炎症可溶性细胞因子及其特异性自身抗体的分泌

Sylvie Carmona^1,2, Jehanne Aghzadi¹, Thierry Vincent³

¹Aix Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.

|December 6, 2024

概括

这项研究在多发性硬化症 (MS) 患者中发现了更高可溶性TWEAK (sTWEAK) 和更低可溶性TNFɑ (sTNFɑ). 对TWEAK (TWAb) 的自身抗体在患有轻度疾病的年轻多发性硬化症患者中更为普遍,这表明MS的新生物标志物潜力.

科学领域:

神经免疫学神经免疫学
生物标志物发现发现
炎症性疾病炎症性疾病

背景情况:

多发性硬化症 (MS) 是一种由免疫失调驱动的慢性中枢神经系统炎症性疾病.
了解TNFɑ和TWEAK等促炎细胞因子及其自身抗体,对于MS的发病和个性化治疗至关重要.
像GFAP和NfL这样的现有生物标志物需要补充的标志物来全面监测MS患者.

研究的目的:

在MS患者中调查瘤亡因子-alpha (TNFɑ) 和TWEAK以及它们的自身抗体 (TNAb,TWAb) 的水平.
探索这些标记物与个性化多发性硬化治疗的临床特征之间的关联.
评估这些标志物与已知生物标志物 (GFAP,NfL) 在MS患者管理中的有用性.

主要方法:

使用ELISA分析了150名多发性硬化患者和186名健康对照 (HC) 的血清样本.
可溶性TNFɑ (sTNFɑ),可溶性TWEAK (sTWEAK),TNAb和TWAb水平的量化. 这是一个非常简单的方法.
在MS患者和HC患者之间比较标志物水平和自身抗体患病率,并与临床数据相关联.

主要成果:

与HC相比,MS患者的sTWEAK水平显著更高,sTNFɑ水平更低.
在MS患者 (10%) 中,TWAb的患病率明显高于HC患者 (4%);TNAb仅在一名患者中被检测到.
TWAb阳性多发性硬化症患者年轻,EDSS得分较低,疾病持续时间较短,并且主要是复发性复发性多发性硬化症表型.

结论:

sTWEAK,sTNFɑ和TWAb代表了MS的潜在新生物标志物.
TWAb的阳性与特定的临床特征相关,这表明它在疾病调节中的作用.
这些发现支持开发一个全面的生物标志物小组,以改善多发性硬化患者的管理和个性化治疗策略.

关键词:

自动抗体是一种自身抗体.细胞因子 (cytokines) 是一种细胞因子.多发性硬化症是多发性硬化症.神经炎症是一种神经炎症.两个弱点.

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