胆固醇,甘油三和葡萄糖水平在美国出生队列中的水平
Xiaoning Huang1, Lucia C Petito2, Nilay S Shah1,2
1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
JAMA network open
|December 6, 2024
概括
心脏代谢健康趋势显示胆固醇和甘油三的改善速度正在减缓,美国年轻成年人的不良葡萄糖趋势正在加速. 身体质量指数 (BMI) 的上升部分解释了这些模式,强调了需要公共卫生干预的必要性.
科学领域:
- 心血管健康 心血管健康
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 在美国,总胆固醇和禁食甘油三的平均水平已经下降.
- 然而,心脏代谢健康的改善可能在年轻人群中减缓.
- 与此同时,糖尿病和肥胖的患病率有所增加,特别是在65岁以下的成年人中.
研究的目的:
- 量化全国总胆固醇,禁食甘油三和禁食葡萄糖水平在出生队列 (1920-1999年) 的趋势.
- 检查这些趋势与身体质量指数 (BMI) 之间的关联.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (1999-2020) 进行的连续横截面研究.
- 对八个10年出生队伍 (1920-1999年) 的分析.
- 量子回归模型用于评估心脏代谢结果每十年的平均变化,BMI作为潜在的调解者.
主要成果:
- 平均差异每一个十年年轻的出生队列: -7.1 mg/dL (总胆固醇), -13.1 mg/dL (三糖化物), +2.7 mg/dL (葡萄糖).
- 身体质量指数 (BMI) 部分调解了出生队列和脂质水平之间的关联,并加强了与葡萄糖水平的关联.
- 高达80%的出生队列与心脏代谢结果之间的关联不是由BMI调解的.
结论:
- 在最近的出生队伍中,总胆固醇和甘油三水平在人口水平上的改善已经减缓.
- 在最近的出生队伍中,葡萄糖水平的不利趋势加快了,部分是由增加的BMI调解的.
- 针对先前健康行为的公共卫生倡议对于改善代际心脏代谢健康至关重要.
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