塞罗瓦尔婴儿虫KPC-2生产者:在厄瓜多尔报告了第一个隔离物
Fernando Villavicencio1,2,3, Viviana Albán4, Carolina Satán1
1National Reference Center for Antimicrobial Resistance RAM, National Institute for Public Health Research, INSPI, Quito, Ecuador.
概括
这项研究报告了全球首次检测到来自厄瓜多尔的Salmonella Infantis的blaKPC-2基因. 这一发现凸显了在临床环境中监测抗菌素耐药性的迫切需要.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球健康的重大威胁.
- 耐卡巴胺肠道细菌 (CRE) 越来越令人担忧,特别是在医疗机构.
- blaKPC基因,通常由等离子体介导,是碳烯耐药性和水平基因转移的关键驱动因素.
研究的目的:
- 报告全球首次在Salmonella enterica serovar Infantis中识别了blaKPC-2基因.
- 来自厄瓜多尔的临床沙门氏菌ST-32分离物中的抗微生物耐药性遗传决定因素的特征.
主要方法:
- 用全基因组测序 (WGS) 来分析临床隔离物.
- 确定了抗菌素耐药性的遗传决定因素.
- 进行了等离子体分析,以了解基因转移机制.
主要成果:
- blaKPC-2基因首次在厄瓜多尔和全球的沙门氏菌中被检测到.
- 该分离物还携带了blaCTX-M-65基因,表明了多药耐药性.
- 一个结合性等离子体,Kpn-WC17-007-03,被确定,可能有助于水平基因转移.
结论:
- 这一发现强调了沙门氏菌等非肠杆菌物种中抗卡巴因的出现.
- 在Salmonella Infantis中发现的blaKPC-2突出显示了对卡巴胺耐药性的潜在新传播途径.
- 持续监测和对抗药机制的表征对于公共卫生至关重要.
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