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Updated: Jun 5, 2025

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使用祖先序列重建的非血氧化酶的反应路径

Di Yang1,2, Chang-Hwa Chiang1,2, Taveechai Wititsuwannakul1

  • 1Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|December 6, 2024
PubMed
概括

以祖先序列重建 (ASR) 引导的酶工程精确地识别了控制非血铁 (FeII) /α-酸 (α-KG) 依赖氧酶通路的关键残留物. 这种策略成功地设计了新型氧化环扩张反应的酶.

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