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Updated: Jun 5, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
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氨基酸通过调节蛋白质-蛋白质相互作用,在体外和体内调节液体-液体相分离

Xufeng Xu1, Aleksander A Rebane2,3, Laura Roset Julia1

  • 1Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.

Proceedings of the National Academy of Sciences of the United States of America
|December 6, 2024
PubMed
概括

氨基酸 (AAs) 可以抑制细胞中的液-液相分离 (LLPS) 和应力颗粒 (SG) 的形成. 诸如林,谷氨酸和甘氨酸等特定的AAs显示出显著的抑制作用,为GS相关疾病提供了潜在的治疗策略.

关键词:
氨基酸氨基酸是一种氨基酸.生物分子凝聚剂的生物分子凝聚剂液态液态相隔离器 液态液态相隔离器蛋白质蛋白质相互作用应力颗粒的压力颗粒

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