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Kaplan-Meier Approach01:24

Kaplan-Meier Approach

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The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
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使用模型选择和贝叶斯适配方法的单个时间点剂量测量:概念验证.

Bisma B Patrianesha1, Steffie M B Peters2, Deni Hardiansyah3

  • 1Medical Physics and Biophysics, Physics Department, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia; Directorate of Nuclear Facility Management, National Research and Innovation Agency (BRIN), Tangerang Selatan, 15314 Banten, Indonesia.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
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PubMed
概括

本研究介绍了一种模型选择方法,用于使用贝叶斯拟合 (BF) 和单个时间点 (STP) 成像进行简化剂量测量. 拟议的STP-BF方法与模型选择显示出优越的性能,相比Hänscheid方法的[177Lu]Lu-PSMA-617剂量测量.

关键词:
贝叶斯的适配是贝叶斯的适配.基于人口的模型选择选择.单个时间点剂量计.

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科学领域:

  • 核医学是一种核医学.
  • 放射性药物疗法是一种放射性药物疗法.
  • 医学物理 医学物理

背景情况:

  • 精确的剂量测量对于优化放射性药物治疗至关重要,特别是用于转移性割抵抗性前列腺癌 (mCRPC) 的[177Lu]Lu-PSMA-617等药物.
  • 简化剂量测量方法,如单个时间点 (STP) 成像,对于临床效率是可取的,但需要强大的模型选择以获得准确性.
  • 贝叶斯拟合 (BF) 为药理动力学建模和剂量计计算提供了一个灵活的框架.

研究的目的:

  • 通过贝叶斯拟合 (BF) 和单一时间点 (STP) 成像来评估不同运动模型对剂量测量的影响.
  • 确定在[177Lu]Lu-PSMA-617治疗中计算脏总摄取量 (TIAC) 的最佳模型.
  • 为了比较拟议的STP-BF方法的性能与已建立的剂量测量技术.

主要方法:

  • 分析了mHSPC患者的[177Lu]Lu-PSMA-617 SPECT/CT扫描中的生物动力学数据.
  • 通过使用Akaike权重进行模型选择,对11种不同的动力模型进行了适合性评估.
  • 模型平均值被用于计算基准脏总摄取量 (TIAC_REF).
  • 进行单点时间贝叶斯拟合 (STP-BF) 来推导STP TIACs (TIAC_STP-BF),并与TIAC_REF和Hänscheid方法进行比较.

主要成果:

  • 一个具有共享参数 (λ2) 的特定双指数函数被确定为最合适的模型,达到57.91%的Akaike权重.
  • 使用所选模型的STP-BF方法产生了不同时间点的8.4%至20.3%的平方根平均误差 (RMSE).
  • 与STP-BF方法相比,Hänscheid方法在评估的时间点中显示出更高的RMSE (14.6%至22.4%).

结论:

  • 在[177Lu]Lu-PSMA-617脏剂量计中,模型选择对于精确的简化剂量测量至关重要.
  • 建议的STP-BF方法,以严格的模型选择为指导,提供比传统的汉斯海德方法更准确的剂量测量估计.
  • 这种优化的STP-BF方法在临床实践中提高了剂量计的可靠性.