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在卵泡液中的可溶性黄质化激素受体和在IVF和ICSI期间与生殖功能的关联

Li Juel Mortensen¹, Mette Lorenzen², Christine Hjorth Andreassen²

¹Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Growth and Reproduction, and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Denmark.

Reproductive biology

|December 6, 2024

概括

血清和卵泡液中的可溶性黄化激素/胆激素受体 (sLHCGR) 水平在辅助生殖技术 (ART) 周期中没有预测怀孕或活产率. 需要进一步的研究来澄清sLHCGR在卵巢功能中的作用.

科学领域:

生殖内分泌学生殖内分泌学
生物标志物发现发现
辅助生殖技术 (ART) 是一种辅助生殖技术.

背景情况:

辅助生殖技术 (ART) 的使用在全球范围内不断增加,需要生物标志物来提高成功率.
血清中的可溶性黄质化激素/胆激素受体 (sLHCGR) 已被提议作为ART结果的预测因素.
在ART的背景下,sLHCGR的起源和预测价值仍然不清楚.

研究的目的:

为了调查sLHCGR (卵巢与外腺) 的起源.
为了确定血清或卵泡液的sLHCGR水平是否可以预测ART后的怀孕或活产.
探索sLHCGR与其他生殖激素和标记物之间的关联.

主要方法:

对133名接受203次ART周期的妇女血清和卵泡液中sLHCGR水平的分析.
对sLHCGR水平与其他生物标志物之间的相关性分析,包括SHBG,自由,AMH和 antral毛囊数量.
统计评估,以评估sLHCGR对ART结果的预测能力.

主要成果:

血清sLHCGR水平明显高于毛囊液水平,这表明其起源于外.
在血清和卵泡液之间观察到正相关性. sLHCGR.
sLHCGR水平与腹毛囊数量无关,不能预测这一队列的怀孕或活产率.

结论:

sLHCGR可能起源于外腺来源,而不是直接来自卵巢毛囊.
目前的证据不支持使用血清或卵泡液sLHCGR作为ART成功的预测生物标志物.
需要进一步的研究来阐明sLHCGR在生殖过程中的确切作用.

关键词:

毛囊液是什么? 毛囊液是什么?美国国务院调查局 (ICSI)在这个过程中,IVF IVF.流化激素的使用方法

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