在结直肠癌中透瘤的免疫细胞
Sonia A M Ferkel1, Elizabeth A Holman1, Raoul S Sojwal1
1Stanford University, School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford, USA.
Neoplasia (New York, N.Y.)
|December 6, 2024
概括
本综述详细介绍了结直肠癌 (CRC) 中瘤透性免疫细胞的细节,强调了它们的各种角色和预后意义. 了解这些免疫特征是开发向免疫疗法和个性化CRC治疗的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 精准医学是一门精准的医学.
背景情况:
- 大肠直肠癌 (CRC) 是一种复杂的疾病,具有不同的病理生理机制和免疫反应.
- 瘤透免疫细胞 (TIIC) 在CRC中起着关键作用,但它们的识别和功能特征是具有挑战性的.
- 免疫细胞定义和识别策略的变化阻碍了对瘤微环境中的细胞间机制的理解.
研究的目的:
- 在CRC中编制和审查关于TIIC的人类和非人类研究.
- 提供免疫亚型,其功能和CRC的预后价值的概述.
- 讨论如何区分免疫特征可以告知免疫治疗目标和个性化治疗策略.
主要方法:
- 在整个免疫谱中对人类蛋白质生物标志物概况的全面分析.
- 对结直肠瘤中TIICs的现有文献的审查.
- 检查各种免疫亚型的病理生理功能和预后作用.
主要成果:
- TIIC在CRC中表现出显著的异质性,影响治疗反应和预后.
- 独特的免疫特征对于理解瘤微环境相互作用至关重要.
- 蛋白质生物标志物概况为TIIC研究提供了更好的解释性.
结论:
- 在CRC中区分免疫特征对于促进免疫疗法和精准医学的发展至关重要.
- 了解TIIC的作用可以指导新型免疫治疗点的开发.
- 通过分析免疫特征,可以增强CRC患者的个性化治疗方案.
相关概念视频
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
01:27Tumor Immunotherapy
476
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
476