曼诺代谢重塑T细胞分化,以增强抗瘤免疫力
Yajing Qiu1, Yapeng Su2, Ermei Xie1
1National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China; Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
用D-曼诺斯恢复T细胞中的曼诺斯代谢,增强了抗瘤活性,并保持了茎状. 这种方法可以提高T细胞的功能,从而改善癌症免疫治疗的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢途径 代谢途径
- 癌症研究 癌症研究
背景情况:
- 细胞代谢极大地影响T细胞功能,包括抗瘤功效.
- T细胞功能障碍通常与曼诺糖代谢受损有关.
- 了解代谢调节是提高基于T细胞的疗法的关键.
研究的目的:
- 研究曼诺代谢在T细胞功能障碍和治疗潜力的作用.
- 探索D-曼诺斯作为一种恢复T细胞功能和干细胞的策略.
- 阐明D-曼诺斯介导的T细胞增强背后的分子机制.
主要方法:
- 对T细胞的单细胞代谢分析.
- 在体外和体内实验中使用D-曼诺补充剂的实验.
- 评估T细胞分化,耗尽和抗瘤活性.
- 涉及O-GlcNAcylation和基因表达的机制研究 (Tcf7).
主要成果:
- 降低曼诺斯代谢与T细胞功能障碍相关.
- 补充D-曼诺斯可以增强抗瘤活性,并减少T细胞耗尽.
- D-曼诺斯促进β-catenin的O-GlcNAcylation,从而保持Tcf7的表达和干性.
- 用D-曼诺斯扩展的T细胞保持干细胞性,并表现出优越的抗瘤疗效.
结论:
- 细胞内在的曼诺代谢调节了CD8+T细胞的命运,将增殖与分化分开.
- 补充D-曼诺代表了癌症免疫治疗的有前途的治疗策略.
- 调节曼诺糖代谢可以提高T细胞在采用疗法中的持久性和有效性.
更多相关视频
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
08:19Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
相关概念视频
The Tumor Microenvironment
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Tumor Immunotherapy
Cell-mediated Immune Responses
Mesenchymal Stem Cells
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
