酸盐修饰氧化碳保护涂料的生物活性特性:形态和功能评估
Magdalena Gawęda1, Jakub Marchewka2, Piotr Jeleń2
1NOMATEN CoE, NOMATEN MAB, National Centre for Nuclear Research, A. Soltana 7 Str., 05-400 Otwock, Poland.
ACS applied materials & interfaces
|December 6, 2024
概括
酸盐和改性无形氧化碳化物 (SiOC) 涂层显示出增强的生物相容性和生物活性. 这些先进的SiOC涂层促进骨细胞的粘附和增殖,使它们成为骨科植入物的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 表面化学 表面化学
背景情况:
- 无形氧化碳化物 (SiOC) 涂层正在探索生物医学应用.
- 提高SiOC的生物相容性和生物活性,而不损害保护性质,对于骨科植入物至关重要.
- 酸离子修饰,以及和的化,正在研究稳定SiOC结构和改善功能特征.
研究的目的:
- 调查用酸盐离子修改并用和化的SiOC涂层的功能性质和形态.
- 评估这些修改对生物相容性,生物活性和保护性质的影响.
- 评估这些改性SiOC涂层在骨科应用中的潜力.
主要方法:
- 溶凝合成和浸泡涂层沉积,随后进行热解以制备SiOC涂层.
- 形态,表面特性,耐腐蚀性和生物活性分析.
- 在体外生物相容性测试使用MG-63骨质母细胞样细胞.
主要成果:
- 氧化涂层呈现均,光滑的表面;在改性SiBPOC中发生了相分离.
- SiPOC和SiBPOC涂层表现出适度的水友性和有利的表面自由能量,用于细胞粘附和矿化.
- SiBPOC涂层提供了优越的耐腐蚀性,而SiAlPOC由于裂而表现出较低的耐腐蚀性. 所有样本都显示了酸沉,在SiPOC和SiAlPOC上增强了酸的形成.
- 在体外研究证实了生物相容性,SiPOC和SiBPOC表现出卓越的生物活性,细胞粘附和增殖.
结论:
- 酸盐和改性SiOC涂层 (SiPOC,SiBPOC) 对骨科应用具有显著的潜力.
- 这些改性涂料提供了生物相容性,生物活性和稳定性的有希望的组合.
- 这些发现表明,这些先进的SiOC材料可以增强骨植入物中的骨整合.
相关概念视频
Carbon Skeletons
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
Protecting Groups for Aldehydes and Ketones: Introduction
Protecting groups are compounds that can bind to a specific functional group in the presence of other functional groups to protect them from undesired chemical reactions. These compounds can selectively bind to particular functional groups and advance chemoselective reactions in polyfunctional systems (Figure 1). After the functional group has served its purpose, it is removed by reacting it with specific compounds.
Bicarbonate-Carbonic Acid Buffer
The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:
Carbonation Shrinkage
Atmospheric CO2 penetrates the concrete's pores and, in the presence of moisture, forms carbonic acid, which then reacts with calcium hydroxide in the hydrated cement, forming calcium carbonate. This process reduces the concrete's volume and is termed carbonation shrinkage.
The concrete's permeability is slightly reduced as calcium carbonate produced during the reaction fills its pores. Furthermore, its strength is slightly enhanced as the water released during the reaction facilitates the...
The concrete's permeability is slightly reduced as calcium carbonate produced during the reaction fills its pores. Furthermore, its strength is slightly enhanced as the water released during the reaction facilitates the...
Acid Attack on Concrete
When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
The rate at which hydrogen...
Microbial Bioremediation of Pesticides
Pesticides often feature structurally complex chemical architectures, incorporating halogen groups and multiple aromatic rings. These characteristics confer high chemical stability, rendering many pesticides resistant to natural degradation processes. This resistance poses significant environmental concerns, as persistent pesticide residues can accumulate in ecosystems and affect non-target organisms.Despite the inherent stability of many pesticides, certain microorganisms possess the metabolic...


