在药物未使用的第一发重度抑郁症中出现的时光平行体结构功能合异常
Qian Zhang1, Aoxiang Zhang1, Ziyuan Zhao2
1Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China.
Progress in neuro-psychopharmacology & biological psychiatry
|December 6, 2024
概括
与焦虑相关的严重抑郁症 (MDD) 显示了大脑连接的改变. 具体来说,焦虑抑郁症 (MDD-ANX) 中的右海马体表现出增加的结构功能连接 (SC-FC) 合,与网络效率相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 网络科学 网络科学
背景情况:
- 重度抑郁症 (MDD) 是一种具有显著异质性的复杂大脑疾病.
- 焦虑性抑郁症 (MDD-ANX) 是一种由同时出现焦虑症状的亚型,需要对其神经支进行进一步的研究.
- 了解结构连接 (SC) 和功能连接 (FC) 之间的相互作用对于阐明MDD病理生理学至关重要.
研究的目的:
- 在第一次发作,从未接受过治疗的MDD患者和健康对照者 (HC) 中,研究系统和区域层面的结构功能连接 (SC-FC) 合.
- 为了比较SC-FC合和MDD亚型 (MDD-ANX,MDD-NANX) 和HC之间的拓特征.
- 评估SC-FC合变化与网络拓和临床特征之间的相关性.
主要方法:
- 在80名MDD患者和80名HC患者中研究了SC-FC合.
- 进行了小组分析,比较了MDD-ANX,MDD-NANX和HC组.
- 检查了拓性质和与合变化和临床数据的相关性.
主要成果:
- 与HC相比,MDD患者在系统 (右海马体,左上旋) 呈现出增加的SC-FC合,并在系统 (右后中心旋,左角旋) 减少合.
- 在MDD的时间和状区域显示,模块间连接受到干扰,结构网络效率受损.
- 与MDD-NANX相比,右海马体在MDD-ANX中显著增加了SC-FC合,与结构网络效率有明显的相关性.
结论:
- 在部和部区域的SC-FC合和网络拓学的变化突显了MDD中结构和功能性大脑异常之间的相互作用.
- 与结构网络效率相关的右海马体的SC-FC合变化可能在焦虑抑郁症的神经病理学中发挥作用.
相关概念视频
Depressive Disorders: Etiology
49
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
49
Dissociative Disorders
31
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
31
Biological Causes of Schizophrenia
46
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
46
Depression: Overview
215
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
215
Attention-Deficit/Hyperactivity Disorder
40
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
40
Antidepressant Drugs: MAOIs and Other Agents
194
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
194


