微阵列贴片的应用用于微剂量的迷幻药物通过皮肤给药
Octavio E Fandiño1, Aaron R J Hutton2, Chunyang Zhang1
1School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK.
概括
形成水凝的微阵列贴片 (HF-MAPs) 提供了一种用于微剂量的幻觉化合物,如DMT,5-MeO-DMT和梅斯卡林的新方法. 这种通过皮肤传递的系统显示了治疗应用的有希望的结果,可能减少剂量频率.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 材料科学 材料科学 材料科学
- 神经科学是一个神经科学.
背景情况:
- 迷幻化合物具有历史性的用途和各种心理健康状况的新兴治疗潜力.
- 微剂量涉及消费低感知剂量的迷幻药物,以获得潜在的益处.
- 通过皮肤递送药物提供了可控和持续释放的替代途径.
研究的目的:
- 为了研究水凝形成微阵列贴片 (HF-MAPs) 通过皮肤传递迷幻化合物的疗效.
- 评估使用HF-MAPs的N,N-二甲基三胺 (DMT),5-甲氧-N,N-二甲基三胺 (5-MeO-DMT) 和梅斯卡林 (MES) 的微剂量潜力.
- 为了评估通过HF-MAPs提供的DMT的药理动力学特征,与肌内注射 (IM) 相比.
主要方法:
- 使用聚乙烯 (PVA),聚乙烯 (PVP) 和酸作为交叉连接剂制造HF-MAP.
- 两种含有不同塑化剂 (PEG400和糖醇) 的储配方用于药物输送.
- 在体外透研究中,使用 Franz 细胞与切割的新生猪皮肤进行了透研究.
- 在生体内进行了大鼠的药理动力学研究,以比较DMT的HF-MAP输送与IM输送.
主要成果:
- 在HF-MAP中的PEG400储库中,DMT (60.71%),5-MeO-DMT (59.61%) 和梅斯卡林 (41.85%) 的透率更高.
- 通过HF-MAPs (7186 ng/mL*h) 输送的DMT的AUCt0-final显著高于IM注射 (1803 ng/mL*h) 的大鼠的药理动力学研究.
- HF-MAP输送的DMT导致了大约72%的相对生物可用性,并表明与IM路线相比,剂量频率的潜在减少.
结论:
- HF-MAP技术是一种可行的策略,可以通过皮肤进行迷幻化合物的微剂量,包括DMT,5-MeO-DMT和梅斯卡林.
- 基于PEG400的储配方增强了这些化合物的通过皮肤的透.
- HF-MAPs为迷幻微量剂提供了一个有希望的替代品,可能会改善药理动力学特征并减少给药频率.
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