阿波蛋白B修改了脂蛋白和ASCVD风险之间的关联
Yuhui Lai1, Shaozhao Zhang1, Yue Guo1
1Cardiology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China.
American heart journal
|December 6, 2024
概括
升高的脂蛋白a (Lp[a]) 会增加动脉样硬化心血管疾病 (ASCVD) 的风险,但只有当阿波利波蛋白B (apoB) 也很高时. 测量apoB有助于对高Lp[a]的个体进行ASCVD风险评估.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 流行病学 流行病学
背景情况:
- 升高的脂蛋白a (Lp[a]) 和阿波利波蛋白B (apoB) 是动脉样硬化心血管疾病 (ASCVD) 的独立危险因素.
- 基础研究表明,apoB和Lp之间存在潜在的相互作用.
- 这项研究调查了apoB是否在一次性预防人群中修改了与Lp相关的ASCVD风险.
研究的目的:
- 确定阿波利波蛋白B (apoB) 水平是否显著调节与升高的脂质蛋白 (Lp[a]) 相关的动脉样硬化心血管疾病 (ASCVD) 风险.
- 评估Lp(a) 和apoB在预测ASCVD和冠心病 (CHD) 事件中的相互作用.
主要方法:
- 利用了来自社区动脉样硬化风险研究 (ARIC) 的数据.
- 测量的血Lp (a) 和apoB水平.
- 将升高的Lp (a) 定义为特定种族的最高五分位数,升高的apoB为≥89 mg/dl.
- 调整了心血管风险因素的Cox回归模型,以分析apoB对与Lp相关的ASCVD和CHD风险的修饰作用.
主要成果:
- 在12988名参与者中,升高的apoB (≥89 mg/dl) 和升高的Lp (a) (五分位数5) 独立地与ASCVD有关.
- 在Lp(a) 和apoB (P = 0.002) 之间观察到显著的相互作用.
- 患有高Lp (a) 的个体只有当apoB也升高时,才会增加ASCVD风险 (HR: 1.48;95% CI: 1.34-1.63).
结论:
- 在初级预防中,与脂蛋白 (Lp[a]) 相关的动脉样硬化心血管疾病 (ASCVD) 风险主要在阿波利波蛋白B (apoB) 水平也升高时显而易见.
- 测量apoB可以精细化和语境化ASCVD风险评估对于高Lp的个体.
- 这强调了考虑Lp(a) 和apoB对于全面的心血管风险分层的重要性.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
532
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
532
Factors Affecting Protein-Drug Binding: Drug Interactions
104
Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
104
Factors Affecting Protein-Drug Binding: Protein-Related Factors
122
Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be...
The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be...
122
RNA Editing
8.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
8.9K
Conjugated Proteins
18.2K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.2K
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K


