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Updated: Jun 5, 2025

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

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低度通过重塑细胞骨和增加染色质可访问性来促进天真的多能性

Renhong Lu1, Bowen Lin1, Zheyi Lin1

  • 1State Key Laboratory of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China; Clinical Center for Heart Disease Research, School of Medicine, Tongji University, Shanghai 200120, China; Shanghai Arrhythmia Research Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China; Shanghai Frontiers Center of Nanocatalytic Medicine, Shanghai, 200092, China.

Journal of advanced research
|December 6, 2024
PubMed
概括

低度通过改变细胞结构和基因表达,显著增强了细胞重编程到纯粹的多能性. 这个物理因素重塑细胞骨和基因组,为细胞命运过渡提供了新的见解.

关键词:
染色体的可访问性 染色体的可访问性细胞骨架 细胞骨架奥斯摩拉性是指奥斯摩拉性.在PI3K-AKT-SP1信号传输中.多能干细胞是多能干细胞.重编程 重编程 是一种重编程.

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