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螺旋结构调节了粉-素复合物的复合模式和释放特征
Miao Shao1, Jianbin Ling2, Chunhong Qiu3
1SCUT-Zhuhai Institute of Modern Industrial Innovation, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
International journal of biological macromolecules
|December 6, 2024
概括
具有特定螺旋结构的粉有效地复合素 (CA),控制其释放. 双螺旋粉结构显著减缓素的释放,提高其食品和制药应用的稳定性.
科学领域:
- 食品科学 食品科学 食品科学
- 材料科学 是一种材料科学.
- 生物化学 生化学
背景情况:
- 素 (CA) 具有有价值的生理效应,但其强烈的尖性限制了其使用.
- 开发有效的输送系统对于利用素的益处,同时减轻其敏性至关重要.
研究的目的:
- 为了研究不同的粉结构如何影响素的复合和释放.
- 描述不同结构复杂性的素和粉之间的相互作用.
主要方法:
- 分析了素与无形结构 (AS),单螺旋和无形结构 (SAS) 以及双螺旋,单螺旋和无形结构 (DSAS) 的复合性和稳定性.
- 结构特征利用了核磁共振光谱,X射线衍射,微分扫描热度计,里埃变换红外和拉曼光谱.
- 在模拟口服消化过程中评估了素的释放,评估了水侵蚀和酶水解.
主要成果:
- SAS-CA复合物显示出最高的素含量 (60.1 mg/g) 和增强的稳定性.
- SAS和DSAS与素形成V6I型复合物,通过键和疏水相互作用稳定.
- 由于其双螺旋结构,DSAS-CA复合体表现出最慢的素释放,抵抗侵蚀 (17.1%) 和水解 (3.6%).
结论:
- 粉结构显著影响素的复杂化和受控释放.
- 双螺旋粉结构有效地稳定素并降低其释放速度.
- 量身定制的基于粉的输送系统可以优化食品和制药中的性生物活性物如素的应用.
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