在固态和稀释溶液中具有高保留率的循环德克斯基光剂
Fabiola Spitaleri1, Sandro Dattilo2, Danilo Aleo1
1MEDIVIS, Via Carnazza 34 C, I- 95030 Tremestieri Etneo, Catania, Italy.
Carbohydrate polymers
|December 6, 2024
概括
固体环极-复合体提供稳定,广泛的抗微生物和抗病毒活性,没有细胞毒性. 这些新型的化剂为传统的消毒剂提供了有希望的替代品.
科学领域:
- 材料科学 材料科学 材料科学
- 制药化学 制药化学 制药化学
- 微生物学 微生物学
背景情况:
- 是一种强大的杀菌剂,但其挥发性限制了应用.
- ,像povidone-,提高的稳定性和交付.
- 环极素可以形成包容复合物,具有稳定的潜力.
研究的目的:
- 开发使用环氧的稳定,固态复合物 (iodophors).
- 评估这些新型复合物的抗微生物和抗病毒疗效.
- 评估循环德克斯-复合物的安全性.
主要方法:
- 固体循环德克斯-复合物的制备,含有或不含有化.
- 在水溶液中对含量的稳定性评估.
- 对抗 Staphylococcus epidermidis. 的抗菌活性的评估.
- 对抗人类腺病毒病毒的抗病毒活性评估 5.
- 在人类角膜上皮细胞 (HCE-2) 上进行细胞毒性测试.
主要成果:
- 添加化显著增强了固体复合物中的纳入和稳定性.
- 一些环氧-复合物在水溶液中表现出很好的长期稳定性.
- 综合体表现出强大的抗微生物和抗病毒活性.
- 在人类角膜上皮细胞上没有观察到细胞毒性作用.
结论:
- 环极是有效的平台,可以创建稳定的,固态.
- 固体环氧-复合物为传统的消毒剂提供了一个有希望的,安全的替代品.
- 这些新型配方具有改善的处理,储存和持续释放的潜力.
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