治疗模式和与肺动脉高血压坚持相关的因素
Marta Albanell-Fernández1, María Margalida Mestre1, Belén López1
1Servicio de Farmacia, División de Medicamentos, Hospital Clínico de Barcelona, Universidad sw Barcelona, Barcelona, España.
肺高血压 (PH) 治疗的坚持因评估方法而异. 覆盖日数比例 (PDC) 显示了比简化药物坚持调查问卷 (SMAQ) 更高的坚持,女性性别可能会影响每个SMAQ的坚持.
科学领域:
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 肺高血压 (PH) 需要持续坚持治疗才能有效管理.
- 了解坚持模式对于优化PH患者的治疗结果至关重要.
- 肺动脉高血压 (PAH) 和慢性血栓栓塞性肺高血压 (CTEPH) 是PH的特定形式,需要向治疗.
研究的目的:
- 为了评估PAH和CTEPH患者的治疗坚持.
- 为了确定与治疗坚持相关的因素.
- 描述PH患者的治疗模式.
主要方法:
- 一项为期6个月的观察性,横截面研究在一家三级医院进行.
- 包括的患者至少接受了PH向治疗一年.
- 使用覆盖日数比例 (PDC>80%) 和简化药物坚持调查问卷 (SMAQ) 测量了坚持.
主要成果:
- 总共分析了63名患者和127种治疗方法; 71.4%是女性,平均年龄为59岁.
- PDC的遵守率为93.7%,SMAQ的遵守率为61.9%,方法之间略有不同.
- 女性性别通过SMAQ (OR:0.23) 与较低的坚持相关,但不是PDC. 报告了高治疗效果 (95.2%) 的感知.
结论:
- 根据使用的评估方法 (PDC与SMAQ),PH的治疗坚持有显著差异.
- 根据SMAQ,女性性别可能会对坚持产生负面影响,尽管PDC没有确定影响因素.
- 不同的PH治疗类型之间没有观察到坚持的显著差异.
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