在2022年源不明的急性肝炎期间严重的超氨酸血症2022年发出警报
Ana Martín Costa1, Ignacio Ros Arnal2, Ruth García Romero2
1Servicio de Pediatría, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Anales de pediatria
|December 6, 2024
概括
在2022年SHIC预警或COVID-19大流行期间,儿童严重肝炎的发病率没有显著增加. 然而,SHIC期间显示出更多非特异性传染性症状,表明可能存在新型病原体.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 肝病学 肝病学是一种肝病学.
背景情况:
- "2022年关于儿童未知起源严重肝炎 (SHIC) 的医疗警报强调需要了解其影响.
- 人们对SHIC的病因和临床表现的了解仍然很少.
研究的目的:
- 调查儿童严重急性超氨酸血症 (HTRA) 的发生率,病因和临床特征.
- 为了比较SHIC预警和SARS-CoV-2大流行期间的HTRA趋势与前几年.
主要方法:
- 一项观察性研究分析了从2012年至2022年期间患有严重HTRA (ALT/AST ≥500U/L) 的儿科患者 (0-16岁).
- 来自单个医疗保健区的数据将SHIC警报和SARS-CoV-2大流行时期与历史对照进行了比较.
主要成果:
- 严重的HTRA发病率为每10万个血液检测中的195.28,在SHIC预警 (181.38) 或大流行 (166.09) 期间没有显著差异.
- 不明来源的肝炎占病例的7.42%;中位数为126天的中位数,转氨酶正常化.
- 在SHIC警报期间,发烧,吐和呼吸系统症状增加,以及白蛋白和性酸酶水平降低.
结论:
- 在SHIC警报或SARS-CoV-2大流行期间,没有观察到严重HTRA发病率的显著增加.
- 在SHIC预警期间,出现了非特异性传染性症状增加的趋势,可能表明一种新型传染病原体.
- 严重的HTRA的流行病学趋势在很大程度上保持不变,尽管SHIC警告.
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