寒冷与的适应改善了超重或肥胖的成年人的代谢健康
Adam J Sellers1, Sten M M van Beek1, Dzhansel Hashim1
1Department of Nutrition and Movement Sciences, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Nature metabolism
|December 6, 2024
概括
寒冷与的适应改善了超重或肥胖个体的胰岛素敏感性和代谢健康. 这种生活方式干预可以提高葡萄糖耐受性,并减少代谢障碍的关键风险因素.
科学领域:
- 代谢健康 代谢健康
- 内分泌学 在内分泌学.
- 人体生理学 人体生理学
背景情况:
- 众所周知,冷适应会提高胰岛素敏感性.
- 肌肉收缩,特别是发,似乎是这种代谢益处的必要条件.
- 超重/肥胖和葡萄糖耐受性受损是严重的公共卫生问题.
研究的目的:
- 为了研究寒冷适应和发对口服葡萄糖耐受性的影响.
- 评估对骨肌肉葡萄糖载体4 (GLUT4) 转位的影响.
- 为了评估代谢标志物和血压的变化.
主要方法:
- 15名超重/肥胖的男性和绝经后妇女接受了10天的间歇性寒冷暴露.
- 每天发的诱导时间为1小时.
- 测量了口服葡萄糖耐受性,禁食葡萄糖,脂质,非化脂肪酸和血压.
主要成果:
- 寒冷的适应与发显著改善了口服葡萄糖耐受性.
- 观察到禁食葡萄糖,甘油三和非化脂肪酸的减少.
- 在干预后,血压也下降了.
结论:
- 结合寒冷适应和发是一种有效的生活方式干预.
- 它改善了那些有代谢障碍风险的人的关键代谢参数.
- 这种方法可能为管理与肥胖相关的代谢功能障碍提供一种新的策略.
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