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在中,tDCS对谷氨酸干细胞路径的影响:神经保护和治疗潜力

Filiz Demirdogen¹, Guven Akcay^2,3

¹Department of Neurology, Mengücek Gazi Education and Research Hospital, Binali Yıldırım University, Erzincan, Turkey.

Pflugers Archiv : European journal of physiology

|December 6, 2024

概括

跨直流刺激 (tDCS) 在模型中显示神经保护作用. 它有助于恢复大脑化学物质的平衡,减少氧化压力,改善运动和认知功能.

科学领域:

神经科学是一个神经科学.
神经学神经学
生物化学生物化学

背景情况:

是一种慢性神经系统疾病,由由于大脑电活动异常而导致的经常性发作所标志.
氧化应激和神经递质 (如谷氨酸和GABA) 的失衡与病的发病有关.
Kindling 模型被广泛用于研究的机制和潜在治疗方法.

研究的目的:

研究跨直流刺激 (tDCS) 对的治疗效果.
在模型中评估tDCS对氧化应激标志物 (总氧化能力和总抗氧化能力) 和关键神经递质 (离子,谷氨酸,GABA) 和受体 (AMPAR1,NMDAR1) 的影响.
评估tDCS对发作中的运动和认知功能的影响.

主要方法:

采用了一种激发性的模型.
管理的tDCS刺激疗法.
进行行为测试以评估运动和认知功能.
在海马组织中测量了氧化应激标志物 (TOC,TAC) 和Ca2+,谷氨酸,GABA,AMPAR1和NMDAR1的水平.

主要成果:

由PTZ诱导的发作增加了TOC,Ca2+,谷氨酸,GABA,AMPAR1和NMDAR1水平,同时降低了TAC.
在队伍中,tDCS治疗显著降低了Ca2+,TOC,谷氨酸,GABA,AMPAR1和NMDAR1水平.
tDCS的管理导致了TAC水平的显著增加.
tDCS对运动和认知功能表现出神经保护作用.

结论:

在模型中,tDCS表现出显著的神经保护作用.
tDCS治疗有助于使氧化应激标志物和关键神经递质/受体水平正常化.
这些发现表明tDCS是通过向氧化应激和神经递质失衡来管理的潜在治疗策略.

关键词:

这就是AMPAR1的特点.对于GABA来说,这是一个很好的选择.谷氨酸酸盐的使用方法在海马体内,海马体一个名为NMDAR1的.这是TDCS的TDCS.

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