通过对体感皮层的多电极内皮层微刺激,唤起稳定而精确的触觉感觉
Charles M Greenspon1, Giacomo Valle2, Natalya D Shelchkova3
1Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL, USA. cmgreenspon@uchicago.edu.
Nature biomedical engineering
|December 6, 2024
概括
在由大脑控制的仿生手中恢复触觉反是可以使用皮质内微刺激 (ICMS) 的. 来自多个电极的重叠刺激增强了感觉局部化和强度,改善了脊髓损伤患者的生物手控制.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复医学 康复医学 康复医学
背景情况:
- 恢复感官反对于有效控制由大脑控制的生物四肢至关重要.
- 皮层内微刺激 (ICMS) 为重新引入触觉感觉提供了一个潜在的途径.
- 以前的研究表明ICMS可以唤起感知,但需要对局部化和强度进行系统的调查.
研究的目的:
- 系统地调查ICMS引起的感知在脊髓损伤的个体的局部和强度.
- 为了确定电极放置和刺激参数如何影响感官感知.
- 通过优化ICMS策略来评估改善生物手控制的潜力.
主要方法:
- 三名椎脊髓损伤的参与者接受了针对主要体感皮质的ICMS.
- 预测的ICMS引起的感知领域被追溯分析.
- 测试了参与者本地化单个ICMS表现的能力.
- 评估了来自多个电极的重叠投射场对感觉的影响.
主要成果:
- 由ICMS唤起的感知表现出具有焦点热点和扩散边界的体形组织,随着时间的推移保持稳定.
- 单个电极刺激通常会导致微弱的感觉,阻碍物体定位.
- 来自多个电极的重叠投射场显著改善了感觉定位和强度.
- 增强的感知促进了更精确的生物手的使用.
结论:
- 在脊髓损伤的个体中,ICMS可以唤起体质组织的触觉感知.
- 通过重叠来自多个电极的投射场来优化ICMS可以增强感官反.
- 这种方法有望提高由大脑控制的生物手的灵巧性和功能.
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