基于代理物的Mycobacterium结核病传播建模:一个系统审查
Viet Long Bui1, Angus E Hughes2, Romain Ragonnet2
1School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. viet.bui1@monash.edu.
基于代理的模型 (ABM) 为了解结核病 (TB) 传播提供了详细的方法,捕捉了复杂的人口动态,通常被传统模型遗漏. 通过共享代码提高透明度是未来结核病研究的关键.
科学领域:
- 流行病学 流行病学
- 计算生物学 计算生物学
- 公共卫生建模公共卫生建模
背景情况:
- 传统的流行病学模型过于简化了Mycobacterium结核病 (M.tb) 传播动态.
- 基于代理的建模 (ABM) 越来越多地被认为具有代表复杂的结核病传播异质性的能力.
研究的目的:
- 系统地审查ABM在模拟M.tb传输中的应用.
- 确定使用ABM用于结核病研究的挑战和机遇.
主要方法:
- 在四个数据库 (MEDLINE,EMBASE,全球健康,Scopus) 中按照PRISMA指南进行系统的文献搜索.
- 包括经过同行评审的文章 (英语,截至2022年12月) 使用基于代理的,基于个体的或微模拟的M.tb传播模型.
- 不包括仅关注体外或宿主内部动态的模型;对方法,流行病学和计算特征的数据提取.
主要成果:
- 从最初的5,077.7项研究中,包括了26项研究.
- 包括的研究因人口设置,时间地平线和模型复杂性而有所不同,许多研究包含异质性和家庭结构.
- 只有八项研究提供了公开可访问的代码,这表明需要提高透明度和可重复性.
结论:
- 针对结核病等复杂疾病动态,ABM具有多功能,解决异质混合和家庭传播问题.
- 挑战包括随机性,参数调整和高计算成本.
- 建议包括开源代码共享和标准化报告,以提高结核病研究的ABM可靠性和可重复性.
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