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行为调节可以改变小鼠甲状腺皮层途径中神经元的视觉调节

Karolina Z Socha¹, João Couto², Matthew R Whiteway³

¹Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Neuro-Electronics Research Flanders, 3000 Leuven, Belgium; Department of Biology & Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium.

|December 7, 2024

概括

像瞳孔扩张和运动等行为状态会影响大脑中的视觉处理. 考虑到这些动态,视觉皮层视觉路径中保留了视网膜表征.

科学领域:

神经科学是一个神经科学.
视觉处理视觉处理
感官系统感官系统

背景情况:

行为状态调节视网膜和背侧生殖细胞核 (dLGN) 中的神经处理.
这些行为影响对视觉调的确切影响尚未完全理解.
了解这些动态对于解释神经活动至关重要.

研究的目的:

描述醒着的小鼠的主要视觉皮层中DLGN轴突的活动动态.
研究视觉刺激,瞳孔大小,静止,运动和麻醉对DLGN轴突活动的影响.
为了确定行为调制如何影响视觉调和在视觉thalamocortical通路中的表示.

主要方法:

在清醒,行为小鼠中利用了2光子功能成像.
在初级视觉皮层记录dLGN轴突活动.
操纵和监测行为状态,包括视觉刺激,瞳孔大小,运动和静止,以及麻醉.

主要成果:

鼻腔视觉运动诱导瞳孔扩张和运动,增强DLGN轴突的响应能力.
调整到鼻腔运动的按在特定的行为状态中过度表现.
这些行为效应在安静的清醒状态下突出,在移动时减少,在麻醉下不存在.
为动态响应变化进行校正,将调整偏差降到最低.

结论:

刺激驱动的行为调制可以显著改变神经调,并偏向早期视觉神经元的分类.
视觉 thalamocortical 途径通常保留视觉运动的视网膜表现,当解释行为动态时.
在感官处理实验中考虑行为影响至关重要,以准确解释神经数据.

关键词:

科普:神经科学:神经科学是一门课.2+) 图像成像技术 GCaMPMP 的使用情况.激发性兴奋激发性兴奋醒着的小鼠醒着的小鼠轴子轴子轴子 dLGNN 在线阅读方向选择性的方向选择性方向调调是指向调.漂浮格子漂浮格子漂浮格子视觉视觉视觉视觉视觉视觉视觉运动视觉运动视觉的泰拉木斯 (thalamus) 是一个视觉体.

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