跨性别患者的性别确认激素治疗:对血栓形成风险的影响
Hannah King1, Thalia Padilla Kelley1, Joseph J Shatzel2,3
1Department of Internal Medicine, Oregon Health & Science University, Portland, OR.
Hematology. American Society of Hematology. Education Program
|December 7, 2024
概括
对跨性别个人的性别肯定激素治疗有新兴的血液风险,包括雌激素的血栓形成和的多细胞血症. 仔细监测和个性化管理对于安全有效的护理至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 跨性别者健康 跨性别者健康
背景情况:
- 跨性别个体的性别肯定激素治疗 (GAHT) 的血液病后效应研究不足.
- 对跨性别女性的雌激素治疗显示出可变的不良影响,受剂量和配方的影响.
- 跨性别和性别多样性个体的血栓形成风险是多因素的.
研究的目的:
- 审查当前对与跨性别人士的雌激素和治疗相关的血液风险的理解.
- 突出这一群体中激素治疗的个性化管理策略的重要性.
- 确定需要进一步研究的领域,以优化血液学结果.
主要方法:
- 对跨性别人群中GAHT血液学影响研究的文献综述.
- 对静脉血栓栓塞瘤 (VTE) 的血栓塞瘤风险因素和管理策略的分析在雌激素的变性人群中.
- 检查与丸激素治疗相关的不良影响,包括多细胞血症和铁缺乏症.
主要成果:
- 雌激素治疗具有可变的血栓形成风险,需要标准抗凝药和共享VTE管理决策.
- 性别肯定性丸激素治疗与低血栓风险相关,但常见的副作用包括多细胞血症和潜在的铁缺乏症.
- 高激素增高激素的好处,如降低抑郁和自杀风险,强调需要仔细管理VTE后的荷尔蒙疗法.
结论:
- 目前关于跨性别人群中GAHT的血液学后果的数据正在扩大,但有限.
- 进一步的研究对于完善管理策略和改善激素治疗中跨性别患者的血液学结果至关重要.
- 需要一个细微的方法,平衡GAHT的好处与潜在的血液风险.
更多相关视频
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.1K
07:37Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids
Published on: August 16, 2024
1.1K
相关概念视频
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
468
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
468
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
616
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
616
01:18Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
147
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
147
01:19Factors Affecting Drug Biotransformation: Biological
110
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
110
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K