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Updated: Jun 5, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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复发性/耐火性CLL: allo-SCT,CAR-T和T细胞参与者的作用

Arnon P Kater1, Tanya Siddiqi2

  • 1Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Hematology. American Society of Hematology. Education Program
|December 7, 2024
PubMed
概括

新型免疫疗法,包括CAR T细胞疗法和双特异性抗体,为慢性淋巴细胞白血病 (CLL) 患者提供了新的希望,这些患者对当前治疗有抗性. 研究重点是克服T细胞功能障碍,以获得更持久,更有效的CLL治疗.

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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