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泡细胞血管肉瘤类似于一个Xanthomatous Histiocytic透,没有血管恶性病的证据

Jolee Potts¹, George J Harocopos^2,3, Aaron J Russell^1,2

¹Department of Medicine, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA.

Journal of cutaneous pathology

|December 7, 2024

概括

泡细胞血管肉瘤是一种罕见的癌症. 这一案例突出了诊断挑战,强调ERG是识别这种内皮细胞恶性瘤的关键标记,当血管特征最小时.

科学领域:

在瘤学瘤学.
皮肤病理学皮肤病理学
血管生物学血管生物学

背景情况:

血管肉瘤是一种罕见的,侵略性的内皮细胞癌.
泡细胞血管肉瘤是一种变体,具有带有细胞质真空化的内皮细胞.
区分泡状细胞血管肉瘤与囊细胞过程可能是具有挑战性的.

研究的目的:

在泡细胞血管肉瘤的病例中提出诊断挑战.
突出免疫组织化学标记在诊断罕见血管肉瘤变体中的有用性.
强调ERG在区分泡状细胞血管肉瘤与模仿者的重要性.

主要方法:

一个59岁的男性的病例报告,中脸和眼皮胀.
多次活检分析了他的病原学和通过免疫组织化学.
考虑的差异诊断包括埃尔德海姆-切斯特病和朗格汉斯细胞囊细胞瘤.

主要成果:

最初的活检显示了泡状单核细胞,模仿了托马斯的过程.
随后的活检显示出异常的内皮细胞和不规则的血管空间,证实了血管肉瘤.
免疫组织化学显示,泡细胞中CD31和ERG的表达,支持内皮细胞的起源.
CD34是负的. 这是负的.

结论:

泡细胞血管肉瘤可以呈现具有挑战性的基因病理特征.
ERG是诊断泡状细胞血管肉瘤的关键标志物,特别是当血管增殖不明显时.
准确的诊断依赖于整合临床,组织病理学和免疫组织化学发现.

关键词:

血管瘤是一种血管瘤.囊细胞透到囊细胞内.血管的恶性瘤.

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