在英国评估他类药物治疗的长期有效性和成本效益:使用个人参与者数据集的建模研究
Borislava Mihaylova1,2, Runguo Wu2, Junwen Zhou1
1Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Health technology assessment (Winchester, England)
|December 7, 2024
概括
类固醇药物治疗在40岁及以上的英国成年人心血管疾病预防方面具有成本效益. 标准和高强度他类药物都有好处,高强度的他类药物对高风险人群来说更具成本效益.
科学领域:
- 心血管疾病的研究研究.
- 卫生经济学 卫生经济学
- 药物治疗 药物治疗
背景情况:
- 心血管疾病 (CVD) 仍然是发达国家的重大健康负担.
- 立方体治疗是预防心血管疾病的一个关键干预措施.
研究的目的:
- 评估英国他类药物治疗的有效性和成本效益.
- 分析不同人口子组的他类药物治疗.
主要方法:
- 使用来自胆固醇治疗试验者的协作和英国生物银行的数据开发了一种心血管疾病微型模拟模型.
- 该模型预测了心血管事件,死亡率,生活质量和医疗保健成本.
- 分析包括40至70岁和≥70岁的参与者,按心血管疾病风险和LDL胆固醇水平分层.
主要成果:
- 终身标准他类药物治疗增加了40-70岁的人的质量调整寿命年 (QALY) 0.20-1.09,70岁以上的人的0.24-0.70.
- 高强度的他类药物提供了额外的QALY增长.
- 在所有分析组 (40-70岁) 中,标准他类药物治疗具有成本效益,每QALY的增量成本从280英到8530英不等.
- 高强度的他类药物对高风险个体和LDL胆固醇升高的人来说具有成本效益.
- 对于70岁以上的个人来说,这两种他类药物强度都是具有成本效益的,每QALY的增量成本低于3500英 (标准) 和11,780英 (高强度).
结论:
- 在英国,低成本的他类药物治疗对所有40岁以上的男性和女性来说都是具有成本效益的.
- 高强度的他类药物治疗对于心血管疾病风险较高或LDL胆固醇升高的人来说特别具有成本效益.
- 研究结果支持在英国广泛使用他类药物用于初级和二级心血管疾病预防.
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