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GDF-15作为表观遗传衰老的代理:与生物年龄标志物的关联,以及身体功能

Margalida Torrens-Mas^1,2, Cayetano Navas-Enamorado¹, Aina Galmes-Panades^3,4

¹Translational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), 07120, Palma, Spain.

|December 7, 2024

概括

增长分化因子15 (GDF-15) 随着年龄的增长而增加,并与表观遗传衰老标志物相关联. 这种生物标志物可能有助于评估与年龄相关的功能衰退,并且比DNA甲基化更容易测量.

科学领域:

衰老的生物标志物
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
老年学是一门学科.

背景情况:

增长差异化因子15 (GDF-15) 是一种与衰老过程相关的新兴生物标志物.
它在健康衰老中的作用和与生物年龄标志物的关联需要进一步研究.

研究的目的:

在健康个体中研究循环GDF-15水平.
探索GDF-15和表观遗传衰老之间的关联 (DNA甲基化钟).
检查GDF-15与身体表现和其他与年龄相关的生物标志物的关系.

主要方法:

在72名健康参与者中使用ELISA量化GDF-15水平.
评估身体功能,身体组成和一般健康状况.
与多个DNA甲基化时钟相关联的GDF-15 (GrimAge,PhenoAge,Hannum,Zhang).

主要成果:

随着年龄的增长,GDF-15水平显著增加,特别是在60岁以上.
GDF-15与表观遗传衰老时钟 (GrimAge,PhenoAge,Hannum,Zhang) 有积极的相关性.
升高的GDF-15与血糖控制受损,炎症和身体功能 (肺功能,握力) 降低有关,特别是在男性中.

结论:

GDF-15是生物衰老和与年龄相关的功能衰退的潜在生物标志物.
GDF-15显示出与表观遗传衰老标志物的强烈关联.
它的测量方便为健康评估提供了与DNA甲基化相比的临床优势.

关键词:

衰老的衰老衰老的衰老生物衰老生物衰老基因表观表观表观时间表.这是GDF-15的GDF-15.炎症炎症是一种炎症.身体的表现身体的表现

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