食补充剂的生物降解性:先进的分析方法来研究人工甜味剂和染料的环境命运
Luisa Mattoli1, Giada Fodaroni1, Giacomo Proietti1
1Metabolomics & Analytical Sciences, Aboca SpA, Località Aboca, 20, Sansepolcro, AR, Italy.
Journal of pharmaceutical and biomedical analysis
|December 7, 2024
概括
补充剂中的人工甜味剂和染料在体内持续存在,并且抵抗废水处理. 这些常见的食品添加剂不易生物降解,构成环境风险.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 生态毒理学 生态毒理学
背景情况:
- 人工甜味剂 (AS) 和合成染料在食品,饮料和药品中普遍存在.
- 这些化合物是持续的环境污染物,原因是废水处理过程中不完全去除.
- 它们不断释放到水生生态系统中,引发了人们对长期环境影响的担忧.
研究的目的:
- 评估9种商业食补充剂的易生物降解性,包括含有AS和合成染料的食补充剂.
- 开发和验证一种染色法,用于在生物降解测试介质中量化特定的AS和染料.
- 为了研究常见的AS和在食补充剂中发现的染料的环境命运.
主要方法:
- 使用了经济合作与发展组织 (OECD) 301F准备生物降解测试 (呼吸计-人计方法).
- 开发并验证了一种超高性能液态色谱 (UHPLC) 方法,与四极飞行时间质谱 (qToF-MS) 和UV-Vis二极管阵列检测 (DAD) 相结合.
- 在生物降解试验介质中的量化阿塞苏尔法K,苏克拉,塔特拉和卡莫辛.
主要成果:
- 虽然整体补充产品显示出良好的生物降解性,但特定的添加剂 (AS和染料) 不容易生物降解.
- 开发的UHPLC-qToF-MS/DAD方法证明在测试介质中量化这些物质是有效的.
- 这些添加剂的持久性表明了潜在的重大环境问题.
结论:
- 在食补充剂中常见的人工甜味剂和合成染料是持久的,不易生物降解的.
- 这种持续性凸显了与这些广泛使用的物质相关的重大环境风险.
- 在医疗保健链和患者中促进意识和明智的选择对于减少持久物质对环境的污染至关重要.
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