前额前部tDCS未能调节年轻人和老年人的记忆检索
Tesnim Arar1, Gabriella V Hirsch1, Taylor A Chamberlain2
1Department of Psychology, University of Chicago, Chicago, IL 60637, USA.
Current biology : CB
|December 7, 2024
概括
在年轻或年长的成年人中,向左侧前额叶皮层 (dlPFC) 进行的阳道跨直流刺激 (tDCS) 并没有改善情节性记忆检索. 这项大型临床试验发现tDCS没有可靠的记忆增强,无论一天中的时间如何.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经调节是一种神经调节.
背景情况:
- 之前的研究表明,向左脊侧前额叶皮质 (dlPFC) 进行的阳横直流刺激 (tDCS) 可能会增强情节性记忆检索.
- 然而,这些影响是不一致的,并可能受到时间等因素的影响.
研究的目的:
- 复制和扩展以前的tDCS关于年轻人和老年人的情节性记忆检索的发现.
- 调查一天中的时间,任务难度和刺激格式对tDCS有效性的影响.
主要方法:
- 一个大规模的,双盲,双人临床试验 (NCT03723850) 涉及150名年轻人和91名老年人.
- 参与者在执行情节性和工作记忆任务之前,接受了阳极tDCS或假刺激到左 dlPFC.
- 实验条件包括早晨与下午的刺激,轻松与艰难的任务以及口头与视觉刺激.
主要成果:
- 在任何年龄组中都没有观察到tDCS或白天时间对情节性或工作记忆表现的显著影响.
- 认知任务表现出敏感性,显示出任务难度和与年龄相关的记忆差异的预期影响.
- 这项研究未能复制tDCS诱导的记忆增强的先前发现.
结论:
- 用标准参数进行一次的tDCS会话并不能可靠地改善年轻人或老年人的情节性记忆检索.
- 这些发现挑战了以前对提升记忆力的积极tDCS结果的概括性.
- 需要进一步的研究来了解tDCS可能调节记忆等认知功能的条件.
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