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循环乙烯硫激活NRF2,以保护其免受氧化应激诱导的计划性亡

Pavel Davidovich1, Dmitriy Nikolaev2, Raniya Khadiullina3

  • 1Trinity College, Dublin, Ireland.

Bioorganic & medicinal chemistry letters
|December 7, 2024
PubMed
概括

循环乙烯硫,如LCB1353,激活NRF2通路,稳定NRF2蛋白并提高其向基因的调节. 这些化合物显示出保护细胞免受氧化应激和铁亡的承诺.

关键词:
细胞死亡 细胞死亡循环乙烯基硫的使用情况铁化是铁化的一种.这就是NRF2的NRF2.编程性亡 (Programmed Necrosis) 是一种有计划性亡的疾病.保护 保护 保护 保护

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