追踪旅程:在老年人群中,使用无线运动囊的胃肠道过渡和内pH动态
Angela Elma Edwina1, Mirko Koziolek2, Nele Steenackers3
1Gerontology and Geriatrics, Department of Public Health and Primary Care, KU Leuven - University of Leuven, Leuven, Belgium.
International journal of pharmaceutics
|December 7, 2024
概括
年龄较大不会显著改变胃肠道 (GI) 生理学,尽管老年住院患者表现出延迟的胃排空. 使用质子抑制剂增加了老年人的胃pH值,具有显著的变化.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 老年医学 老年医学
背景情况:
- 胃肠道 (GI) 的生理变化可能会影响口服药物的吸收,疗效和安全.
- 在老年人群中,消化道生理学研究不足.
- 了解老年人的胃肠道过渡和pH值对于优化药物治疗至关重要.
研究的目的:
- 调查老年住院患者和社区居住的老年人的胃肠道过渡时间和pH值.
- 为了比较老年人的胃肠道生理与健康的年轻志愿者.
- 为了确定影响GI过境和pH的因素,在老龄化人口中.
主要方法:
- 涉及老年住院患者和社区成年人 (≥75岁) 的前性研究.
- 使用无线运动囊系统评估胃肠道过境和内pH值.
- 数据与以前对年轻志愿者的研究汇总在一起;使用多变量回归分析.
主要成果:
- 与年轻志愿者 (p < 0.01) 相比,老年住院患者 (N=8) 的胃空气排放时间较长.
- 居住在社区的老年人 (N=22) 没有表现出延迟的胃空化 (p = 0.85).
- 质子抑制剂 (PPI) 的使用与更高的胃pH相关 (中位数pH为3.75比1.28;p<0.01);老年人小肠pH比年轻人低 (6.8比7.2;p<0.01).
结论:
- 仅仅是年龄的增长不会显著改变胃肠道过渡时间或pH值.
- 延迟胃空却仅在老年住院患者中观察到,而不是社区居住的老年人.
- 质子抑制剂的使用在老年人中提高了胃的pH值,显示出相当大的个体间变化.
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