核心外气凝设计用于增强口服胰岛素的输送
Gozde Ozesme Taylan1, Carlos Illanes-Bordomás2, Ozge Guven3
1Department of Biotechnology, Graduate School of Natural and Applied Sciences, Middle East Technical University, Ankara, Turkey.
International journal of pharmaceutics
|December 7, 2024
概括
新的气凝载体为患者提供了友好的胰岛素口服输送,提高了封装效率和控制在肠道中的释放,与传统注射不同.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 基于蛋白质的疗法通常需要注射,导致患者的不适和频繁的管理.
- 口服蛋白质的输送面临着诸如胃环境中的降解和吸收不良等挑战.
- 气凝具有高孔径和高表面积,为口服蛋白质疗法提供了一个新的平台.
研究的目的:
- 开发和描述基于天然多糖的气凝,用于口服胰岛素的输送.
- 为了比较常规和核心外气凝结构,以增强蛋白质封装.
- 为了评估从开发的气凝中释放的胰岛素的体外释放特征.
主要方法:
- 使用超临界二氧化碳 (sc-CO2) 干燥酸盐凝珠合成的气凝.
- 通过扫描电子显微镜 (SEM) 进行结构分析.
- 福利埃变换红外光谱 (FTIR) 测量结构差异.
- 实验室释放研究在模拟胃液 (SGF) 和模拟肠液 (SIF) 中进行.
主要成果:
- 与传统气凝相比,核心型气凝具有更高的结构均性和多孔性.
- 封装效率对于核心外 (53%) 与传统 (12%) 气凝相比显著更高.
- 核心外气凝在SGF中显示最小的胰岛素释放 (30%),但在一个小时内在SIF中释放了大量的胰岛素 (60%),随后持续释放.
结论:
- 核心的气凝显示出用于口服胰岛素输送的增强载体特性.
- 开发的气凝显示出控制释放短效胰岛素治疗药物的潜力.
- 气凝技术为可注射蛋白质疗法提供了一个有前途的,患者友好的替代方案.
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