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结直肠癌中的肠道微生物群:从致病源到临床

William Fusco¹, Ludovica Bricca², Francesco Kaitsas³

¹Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Department of Medical and Surgical Sciences, UOC CEMAD Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.

Best practice & research. Clinical gastroenterology

|December 7, 2024

概括

结肠直肠癌的发病率正在上升,原因是生活方式的改变影响了肠道微生物群. 微生物组的改变与结直肠癌有关,为新的,准确的诊断生物标志物提供了潜力.

科学领域:

在瘤学瘤学.
微生物学微生物学
胃肠病学胃肠病学

背景情况:

结肠直肠癌 (CRC) 是一个主要的全球健康问题,与西方生活方式和饮食有关的发病率上升.
西洋化推动了肠道微生物组的改变,越来越多地与结直肠瘤发生有关.
目前的CRC查方法,像便免疫化学测试一样,在准确性上有局限性.

研究的目的:

审查当前对肠道微生物群在结直肠癌发展中的作用的理解.
探索基于微生物组的生物标志物用于CRC诊断的潜力.
突出非侵入性CRC查策略的进展.

主要方法:

对研究肠道微生物群和结直肠癌的文献综述.
对将微生物组变化与CRC联系起来的病原遗传机制研究的分析.
对CRC新兴的基于微生物组的诊断生物标志物的评估.

主要成果:

肠道微生物群失生症与结直肠癌有显著的关联.
特定的微生物组成和功能与CRC的发展和进展有关.
微生物组的签名显示出,作为检测CRC的准确,非侵入性生物标志物具有前途.

结论:

肠道微生物群在结直肠癌的发病过程中起着至关重要的作用.
微生物组分析代表了对新型,准确和非侵入性CRC查的有希望的前沿.
对肠道微生物群的进一步研究可能会导致改善CRC的诊断工具和治疗策略.

关键词:

生物标志物生物标志物结肠直肠癌是一种癌症.我们的肠道微生物群.微生物组是一个微生物组.西方饮食是西方人的饮食.

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