炎症和结直肠癌中的肠道微生物群:临床医生的潜在工具箱
Nathan Grellier1, Andrea Severino2, Sebastiano Archilei2
1Department of Hepato-Gastroenterology, Poitiers University Hospital, Poitiers, France.
Best practice & research. Clinical gastroenterology
|December 7, 2024
概括
肠道微生物群在炎症性肠病 (IBD) 和代谢障碍中发生变化,促进慢性炎症,促进结直肠癌 (CRC) 的发展. 了解这种联系可能会提供新的CRC预防和诊断策略.
科学领域:
- 胃肠道学和瘤学
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
背景情况:
- 结肠直肠癌 (CRC) 是一个重要的全球健康问题.
- 西方生活方式相关的慢性疾病,如炎症性肠病 (IBD) 和代谢障碍,增加了CRC的风险.
- 慢性炎症和肠道失调是IBD和代谢性疾病的常见标志,有助于致癌.
研究的目的:
- 审查当前对肠道微生物群在CRC发展中的作用的理解.
- 探索IBD,心脏代谢疾病和肠道微生物群改变之间的共享的前致癌机制.
- 确定肠道微生物群在CRC预防和诊断中的潜在应用.
主要方法:
- 关于肠道微生物群,IBD,代谢疾病和结直肠癌的现有研究的文献综述.
- 分析慢性炎症,肠道失调和癌症发生之间的相互作用.
- 综合证据,将肠道微生物群的变化与特定患者群体的CRC发展联系起来.
主要成果:
- 改变肠道微生物群的组成和功能与IBD和代谢障碍的慢性炎症特征有关.
- 这种慢性炎症是由肠道失调引起的,创造了一个促癌的环境,有利于CRC的发展.
- 肠道微生物群在IBD和心脏代谢疾病中起到共同的前致癌因素的作用.
结论:
- 肠道微生物群在结直肠癌的发展中起着至关重要的作用,特别是在IBD和心脏代谢疾病患者中.
- 准肠道微生物群为预防CRC和早期诊断的新策略提供了一个有希望的途径.
- 对特定微生物机制的进一步研究是有必要的,以将这些发现转化为临床实践.
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