新辅助免疫疗法加化学疗法在高海拔本地人与切除的食道状细胞癌在西藏
Xizhao Sui1, Duoji Danzeng2, Ping Ni2
1Department of Thoracic Surgery, Peking University People's Hospital, China.
Asian journal of surgery
|December 7, 2024
概括
新辅助免疫疗法加化疗对西藏的食道癌症患者是安全有效的. 这种治疗方案,随后是手术,在高海拔地区的人群中显示出有希望的结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠道手术 胃肠道手术
背景情况:
- 新辅助疗法改善了食道状细胞癌 (ESCC) 的存活率.
- 化学放射治疗是标准的,但在西藏是有限的.
- 在西藏ESCC患者中缺乏新辅助免疫疗法加化疗的证据.
研究的目的:
- 评估新辅助免疫疗法加化学疗法的安全性和可行性,用于切除ESCC的西藏患者.
- 为了评估这个特定的高海拔群体的治疗反应和结果.
主要方法:
- 包括以前没有接受过治疗的可切割ESCC患者.
- 手术前的治疗方案:提斯莱利祖马布,纳布-帕克利塔塞尔和卡博普拉丁.
- 手术后计划的新辅助治疗;基于瘤位置的方法.
主要成果:
- 82.6%完成了新辅助治疗; 60.9%接受了R0切除的手术.
- 目标反应率 (ORR) 为69.6%,疾病控制率 (DCR) 为100%,病理完整反应率 (pCR) 为21.4%.
- 与治疗相关的不良事件发生在82.6%,其中47.8%为3-4级;甲状腺毒性观察到52.2%.
结论:
- 新辅助免疫疗法加上化学疗法,然后进行食道切除术,对于西藏的高海拔本地人具有切除ESCC的安全和可行.
- 该疗法表现出令人鼓舞的疗效,具有高的R0切除和pCR率.
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