基因组范围内的基因组基的分子病理与抑郁和自杀相关
Yogesh Dwivedi1, Bhaskar Roy2, Praveen Kumar Korla2
1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. yogeshdwivedi@uabmc.edu.
概括
大脑中的DNA甲基化模式可以区分主要抑郁症 (MDD) 患者与没有自杀行为的患者. 这一发现可能有助于识别那些自杀企图风险较高的人.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 重度抑郁症 (MDD) 的自杀企图率很高,但MDD内的自杀倾向的风险因素仍然不清楚.
- 识别生物学标志物来区分MDD的自杀行为对于有针对性的干预至关重要.
研究的目的:
- 为了研究抑郁症患者与没有自杀行为之间的背侧前额叶皮质的全基因组DNA甲基化差异.
- 确定与MDD中自杀行为相关的特定基因和生物学途径.
主要方法:
- 使用 850K Infinium Methylation EPIC BeadChip进行全基因组DNA甲基化分析.
- 在三组中比较甲基化概况:抑郁自杀 (MDD+S),抑郁非自杀 (MDD-S) 和非精神病控制 (C).
- 不同甲基化基因的功能丰富和途径分析.
主要成果:
- 在所有组比较中观察到DNA甲基化位点和基因的显著差异.
- 一组独特的33,129个独特的甲基化位点和5451个基因将MDD-S与MDD+S组区分开来.
- 途径分析涉及催产素,GABA,VGFA,TNFA和mTOR信号在MDD人口中的自杀行为.
结论:
- 显著的DNA甲基化模式是主要抑郁症中自杀行为的特征.
- 这些发现突出了评估MDD患者自杀风险的潜在表观遗传生物标志物.
- 了解这些分子差异可能为新的治疗策略铺平道路.
相关概念视频
Human Genetics
534
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
534
Depression: Overview
215
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
215
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Genome-wide Association Studies-GWAS
12.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.4K


