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Updated: Jun 5, 2025

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APOE-ε4和运动训练对大脑微血管内皮细胞屏障功能和新陈代谢的影响

Callie M Weber1, Bilal Moiz1, Gabriel S Pena2

  • 1Department of Bioengineering, University of Maryland; College Park, MD, 20742, United States.

EBioMedicine
|December 8, 2024
PubMed
概括

APOE-ε4基因型会损害大脑细胞功能和新陈代谢,增加阿尔茨海默病的风险. 运动血清对APOE-ε3细胞有益,但对APOE-ε4细胞有害,这表明运动干预需要基因型特定的策略.

关键词:
在APOE基因型中,APOE基因型阿尔茨海默病的疾病阿尔茨海默病的疾病.血液-大脑屏障是什么?运动训练是运动训练.葡萄糖的新陈代谢.

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Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
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