关于临床实践中的微生物组测试的国际共识声明
Serena Porcari1, Benjamin H Mullish2, Francesco Asnicar3
1Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
The lancet. Gastroenterology & hepatology
|December 8, 2024
概括
肠道微生物组显示出诊断潜力,但缺乏临床证据. 专家建议标准化实践可靠的人类微生物组测试,以确保临床价值和防止资源浪费.
科学领域:
- 微生物组研究的研究.
- 临床诊断 临床诊断 临床诊断
- 医疗技术评估 医学技术评估
背景情况:
- 越来越多的人对肠道微生物群对医学诊断的兴趣.
- 有限的临床证据证明微生物组测试的有用性.
- 不受监管的直接面向消费者的微生物组测试带来了资源浪费和临床管理不善的风险.
研究的目的:
- 标准化微生物组测试临床实施的最佳实践.
- 建立微生物组诊断的监管框架.
- 尽量减少不适当的测试使用,并促进基于证据的开发.
主要方法:
- 召集了一个国际多学科专家小组.
- 制定了关于原则,要求,适应症,预测,分析,报告和临床价值的建议.
- 评估当前的知识差距和未来的研究方向.
主要成果:
- 建立了微生物组测试的标准化最佳实践.
- 为规范微生物组诊断试验提供了一个框架.
- 确定了未来研发的关键领域.
结论:
- 标准化微生物组测试对于临床实施至关重要.
- 需要一个监管框架来确保微生物组诊断的有效性和实用性.
- 基于证据的开发将优化人类微生物组诊断在医学中的使用.
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