在反动物中,内分泌适应要求苛刻的生理状态
1Department of Animal Science, Cornell University, Ithaca, New York 14853.
Journal of dairy science
|December 8, 2024
概括
高效的反动物利用荷尔蒙适应来管理怀孕和哺乳期间的营养使用. 像FGF21和瘦素这样的新信号是协调奶牛和绵羊新陈代谢的关键.
科学领域:
- 杂动物生理学的内分泌学和新陈代谢.
背景情况:
- 动物需要荷尔蒙适应来优先考虑怀孕和哺乳期间的营养使用.
- 葡萄糖对胎儿发育和乳糖合成至关重要,需要特定的内分泌机制,如胰岛素抵抗.
研究的目的:
- 探索新发现的代谢信号在要求生理状态期间协调反动物代谢中的作用.
- 突出纤维细胞生长因子21 (FGF21) 和乳牛和绵羊中瘦素的重要性.
主要方法:
- 对FGF21和素在反动物生理学中的新兴数据的审查.
- 研究激素调节和关键生命阶段的作用.
主要成果:
- 在20世纪80年代和90年代,生长激素被确定为一种抗胰岛素的信号.
- 来自脂肪组织,肌肉和肝脏的新信号,如FGF21和素,是动态调节的,对跨器官通信至关重要.
- FGF21调节胰岛素的作用,而素则通过下丘脑-垂体-甲状腺轴调节能量分配.
结论:
- 新出现的数据证实了像FGF21和勒这样的新信号在早期哺乳期和晚期怀孕期间的反动物新陈代谢中的重要性.
- 这些信号有可能在高生产力反动物中协调代谢适应.
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