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高龄患者的肺移植结果:两个人总比一个人好吗?

Mark Shacker¹, Sreeja Biswas Roy², Ashwini Arjuna³

¹Creighton University School of Medicine, Phoenix, Ariz.

The Journal of thoracic and cardiovascular surgery

|December 8, 2024

概括

双边肺移植可以提高接受者的生存率,直到74岁. 老年患者 (75-79岁) 和之前接受过心脏手术的患者面临较差的长期结果,需要仔细选择移植.

科学领域:

心脏病学心脏病学
胸部外科手术胸部外科手术
移植手术移植手术

背景情况:

肺移植越来越多地在老年人 (≥65岁) 中进行.
在这个不断增长的人口群体中,结果和风险因素需要进行审查.

研究的目的:

分析不同年龄组的肺移植结果.
确定与老年肺移植接受者的生存率下降相关的风险因素.

主要方法:

美国器官共享网络数据 (2006-2023) 的回顾性审查.
对初级肺移植病例的分析,重点关注接受者的年龄和生存影响.

主要成果:

年长的接受者 (75-79岁) 与年轻群体 (19%) 相比,更有可能接受一次性肺移植 (75%).
双边肺移植在接受者中显示出高达74岁的生存优势.
以前的心脏手术与老年患者的死亡率增加 (HR 1.27) 和单次肺移植的更高率有关.

结论:

双边肺移植在74岁以下的接受者中优于单个肺移植.
75-79岁的肺移植接受者经历了长期生存率的下降.
仔细的患者选择至关重要,特别是对于接受单次肺移植的老年人来说,考虑到之前的心脏手术的风险.

关键词:

高龄的年龄高龄的年龄年龄年龄年龄年龄年龄肺部移植肺部移植结果就是结果.幸存率幸存率生存率

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